Mark's Research
Clinical investigation grounded in molecular biology and focused on cardiac arrhythmias
In Vivo Restoration of Myocardial Conduction With Carbon Nanotube Fibers
Circ Arrhythm Electrophysiol. 2019 Aug;12(8). In press.
Circadian rhythms govern cardiac repolarization and arrhythmogenesis
Nature. 2012 Feb 22;483(7387):96-9.
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Circulation. 2010 Dec 21;122(25):2669-79.
Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome.
Sci Transl Med. 2011 Dec 14;3(113):113ra125.
A new paradigm for predicting risk of torsades de pointes during drug development.
Clin Pharmacol Ther. 2016 Jun 15.
Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients.
Card Electrophysiol Clin. 2016 Jun;8(2):481-93.
Worsening renal function is not associated with response to treatment in acute heart failure
Int J Cardiol. 2013 Sep 1;167(5):1912-7.
Targeting ryanodine receptors for anti-arrhythmic therapy
Acta Pharmacol Sin. Jun 2011; 32(6): 749–757.
Ambulatory ECG recording in mice
J Vis Exp. 2010 May 27;(39).